Article
Insufficient resistance of trehalose-6,6-dimycolate-treated T-cell receptor delta gene mutant (TCR delta-/-) mice against influenza virus infection.
Microbiology and immunology - 1 Jan 1999
Hoq M M, Suzutani T, Nakaya K, Yoshida I, Ogasawara M, Takeda Y, Shibaki T, Itohara S, Yamamoto H, Azuma M
Abstract excerpt
Normal mice inoculated intravenously with 50 microg trehalose-6,6'-dimycolate, a glycolipid component of the cell wall of Mycobacterium, in an oil-in-water emulsion (TDM emulsion) acquired a high resistance to intranasal lethal infection of an influenza virus. In contrast, TDM emulsion-treated T-cell receptor delta gene mutant (TCR delta-/-) mice acquired insufficient resistance against the lethal influenza virus...
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