Article
Reduced risk of AIDS lymphoma in individuals heterozygous for the CCR5-delta32 mutation.
Cancer research - 1 Aug 1999
Dean M, Jacobson L P, McFarlane G, Margolick J B, Jenkins F J, Howard O M, Dong H F, Goedert J J, Buchbinder S, Gomperts E, Vlahov D, Oppenheim J J, O'Brien S J, Carrington M
Abstract excerpt
Non-Hodgkin's lymphoma (NHL) has been increasing in frequency in the industrialized world, but the environmental and genetic factors that contribute to susceptibility are not known. B-cell lymphomas represent a major cause of morbidity and mortality in HIV-infected individuals. The identification of a deletion in the CCR5 chemokine receptor gene that alters the risk for infection and progression to AIDS led us to...
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