Linkage of a marker in intron D of the estrogen synthase locus to rheumatoid arthritis.

doi:10.1002/1529-0131(199908)42:8<1617::AID-ANR8>3.0.CO;2-N

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Linkage of a marker in intron D of the estrogen synthase locus to rheumatoid arthritis.

Arthritis and rheumatism - 1 Aug 1999

John S, Myerscough A, Eyre S, Roby P, Hajeer A, Silman A J, Ollier W E, Worthington J

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OBJECTIVE: To test for the presence of linkage of the estrogen synthase (CYP19) locus to rheumatoid arthritis (RA) in affected sibling pair (ASP) families. METHODS: Two data sets of RA ASPs (225 ASPs and 107 ASPs) were genotyped for a polymorphic tetranucleotide marker at the CYP19 locus using fluorescence-based semiautomated genotyping technology. Evidence of linkage was assessed by estimating allele sharing...

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Linkage of a marker in intron D of the estrogen synthase locus to rheumatoid arthritis.

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