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Article

Parkinson's disease transgenic mitochondrial cybrids generate Lewy inclusion bodies

14 Jan 2004

Abstract excerpt

Many models of Parkinson's disease (PD) have succeeded in replicating dopaminergic neuron loss or alpha-synuclein aggregation but not the formation of classical Lewy bodies, the pathological hallmark of PD. Our cybrid model of sporadic PD was created by introducing the mitochondrial genes from PD patients into neuroblastoma cells that lack mitochondrial DNA. Previous studies using cybrids have shown that...

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PMID: 14756800
DOI: 10.1046/j.1471-4159.2003.02168.x

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