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Article

Paroxysmal nocturnal hemoglobinuria: analysis of the effects of mutant PIG-A on gene expression.

American journal of hematology - 1 Aug 1999

Kanai N, Vreeke T M, Parker C J

Abstract excerpt

Compelling evidence indicates that mutations in PIG-A are necessary for the development of paroxysmal nocturnal hemaglobinuria (PNH), however, it is unclear why mutant PIG-A stem cells have a selective advantage. Further, multiple, discrete PIG-A mutations have been detected in the peripheral blood and bone marrow of patients with PNH, but the contribution of the different mutant clones to hematopoiesis is...

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Source

Identifiers

PMID: 10440907
DOI: 10.1002/(sici)1096-8652(199908)61:4<221::aid-ajh1>3.0.co;2-#

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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