POLYMERASE CHAIN REACTION ASSAYS FOR THE DIAGNOSIS OF INFECTION WITH THE PORCINE ENDOGENOUS RETROVIRUS AND THE DETECTION OF PIG CELLS IN HUMAN AND NONHUMAN RECIPIENTS OF PIG XENOGRAFTS

Abstract excerpt

BACKGROUND: Pigs offer an unlimited source of xenografts for humans. However, recipients of pig xenografts are inevitably exposed to the porcine endogenous retrovirus (PERV), which is carried in the pig germline. The ability of PERV to infect human cells in vitro has heightened safety concerns regarding the transmission of PERV to pig xenograft recipients. METHODS: In response to the need to establish laboratory...

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