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Human Amylin Induces “Apoptotic” Pattern of Gene Expression Concomitant with Cortical Neuronal Apoptosis

1 Aug 1998

Abstract excerpt

Amylin forms large beta-pleated neurotoxic oligomers but shows only 38% sequence similarity to A beta. As patterns of gene expression during neuronal apoptosis appear stimulus and cell type specific, we compared the pattern of amylin-induced gene expression in rat cortical neurons with that shown previously to be induced by A beta in order to evaluate whether these two peptides with different primary but similar...

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PMID: 9681440
DOI: 10.1046/j.1471-4159.1998.71020506.x

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