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Overexpression of multidrug resistance genes MDR1 and cMOAT in human hepatocellular carcinoma and hepatoblastoma cell lines.

1 Sept 1999

Abstract excerpt

Overexpression of either of the multidrug resistance genes MDR1 and MRP is associated with resistance of tumors to multiple chemotherapeutic agents. Overexpression of MDR1 has been reported in some cell lines derived from human hepatocellular carcinomas (HCC) and hepatoblastomas (HB). The human gene for cMOAT ( ), a homologue of MRP, is thought to mediate hepatobiliary excretion of organic anions and to be...

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PMID: 10427140
DOI: 10.3892/ijo.15.3.559

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