Article
Identification of a novel splice variant of heat shock cognate protein 70 after chronic antidepressant treatment in rat frontal cortex.
Biochemical and biophysical research communications - 2 Aug 1999
Yamada M, Yamada M, Kiuchi Y, Nara K, Kanda Y, Morinobu S, Momose K, Oguchi K, Kamijima K, Higuchi T
Abstract excerpt
In this study, we identified a novel splice variant of 70-kDa heat shock cognate protein (HSC70), while screening differentially expressed molecules in rat brain after chronic antidepressant treatment. This clone, named HSC49, lacked 470 bp of nucleotides of rat HSC70. HSC49 encoded 442 amino acid residues with a calculated molecular mass of 48.6 kDa. DNA sequence analysis revealed that HSC49 lacked the entire...
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