Article
An allel-specific abnormal transcript of the heat shock protein 70 gene in patients with major depression.
Biochemical and biophysical research communications - 27 Feb 1996
Shimizu S, Nomura K, Ujihara M, Sakamoto K, Shibata H, Suzuki T, Demura H
Abstract excerpt
Stress-inducible 72-kDa heat shock proteins (HSP70) were encoded on genes in multiple chromosomes. The expression of mRNA transcribed from the gene (HSP70-1) on chromosome 6 was studied using reverse transcript polymerase chain reaction in peripheral blood mononuclear cells of patients with different diseases. The deletion of 29 bp occurred in 5' noncoding and subsequent 133 bp in coding sequences of HSP70 mRNA...
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