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Article

Differential effects of arsenic(III) and chromium(VI) on nuclear transcription factor binding

1 Jul 1999

Abstract excerpt

The toxic metals arsenic(III) and chromium(VI) are considered human carcinogens, although they may act through different mechanisms. We previously showed that when administered at single low, non-overtly toxic doses, chromium, arsenic, and several other chemical carcinogens preferentially alter expression of several model inducible genes in both whole-animal and cell-culture systems. In this study, we assessed...

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PMID: 10411148
DOI: 10.1002/(sici)1098-2744(199907)25:3<219::aid-mc8>3.0.co;2-x

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