Article
Molecular analysis of a spontaneous dystrophin 'knockout' dog.
Neuromuscular disorders : NMD - 1 Jul 1999
Schatzberg S J, Olby N J, Breen M, Anderson L V, Langford C F, Dickens H F, Wilton S D, Zeiss C J, Binns M M, Kornegay J N, Morris G E, Sharp N J
Abstract excerpt
We have determined the molecular basis for skeletal myopathy and dilated cardiomyopathy in two male German short-haired pointer (GSHP) littermates. Analysis of skeletal muscle demonstrated a complete absence of dystrophin on Western blot analysis. PCR analysis of genomic DNA revealed a deletion encompassing the entire dystrophin gene. Molecular cytogenetic analysis of lymphocytes from the dam and both dystrophic...
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