Article
X-linked muscular dystrophy in a Labrador Retriever strain: phenotypic and molecular characterisation.
Skeletal muscle - 7 Aug 2020
Barthélémy Inès, Calmels Nadège, Weiss Robert B, Tiret Laurent, Vulin Adeline, Wein Nicolas, Peccate Cécile, Drougard Carole, Beroud Christophe, Deburgrave Nathalie, Thibaud Jean-Laurent, Escriou Catherine, Punzón Isabel, Garcia Luis, Kaplan Jean-Claude, Flanigan Kevin M, Leturcq France, Blot Stéphane
Abstract excerpt
BACKGROUND: Canine models of Duchenne muscular dystrophy (DMD) are a valuable tool to evaluate potential therapies because they faithfully reproduce the human disease. Several cases of dystrophinopathies have been described in canines, but the Golden Retriever muscular dystrophy (GRMD) model remains the most used in preclinical studies. Here, we report a new spontaneous dystrophinopathy in a Labrador Retriever...
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