Article
Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 1999
Lehtonen J Y, Daviet L, Nahmias C, Horiuchi M, Dzau V J
Abstract excerpt
We previously demonstrated that the intracellular third loop (i3 loop) of angiotensin II type 2 receptor (AT2) plays a key role in mediating the biological functions of this receptor. To determine which residues are important for AT2 signaling, mutated receptors with serial deletions within the i3 loop were stably expressed in PC12 cells. Deletion of residues 240-244 within the intermediate portion of the i3 loop...
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