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Article

An in vivo library-versus-library selection of optimized protein-protein interactions.

Nature biotechnology - 1 Jul 1999

Pelletier J N, Arndt K M, Plückthun A, Michnick S W

Abstract excerpt

We describe a rapid and efficient in vivo library-versus-library screening strategy for identifying optimally interacting pairs of heterodimerizing polypeptides. Two leucine zipper libraries, semi-randomized at the positions adjacent to the hydrophobic core, were genetically fused to either one o...

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PMID: 10404162
DOI: 10.1038/10897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10404162-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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