Serological detection of hepatitis B virus genotypes by ELISA with monoclonal antibodies to type-specific epitopes in the preS2-region product.

doi:10.1016/s0166-0934(99)00039-7

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Article

Serological detection of hepatitis B virus genotypes by ELISA with monoclonal antibodies to type-specific epitopes in the preS2-region product.

Journal of virological methods - 1 Jun 1999

Usuda S, Okamoto H, Iwanari H, Baba K, Tsuda F, Miyakawa Y, Mayumi M

Abstract excerpt

An ELISA was developed for serological determination of the six genotypes of hepatitis B virus (HBV) designated A, B, C, D, E, and F. Monoclonal antibodies were raised against genotype-specific epitopes in the preS2-region product, and labeled with horseradish peroxidase. Hepatitis B surface antigen (HBsAg) in sera was captured by immobilized antibodies against the common determinant, and evaluated for reactivity...

Topics

Amino Acid Sequence
Antibodies, Monoclonal
Antibody Specificity
Enzyme-Linked Immunosorbent Assay
Epitopes, B-Lymphocyte
Genotype
Hepatitis B
Hepatitis B Antibodies
Hepatitis B Surface Antigens
Hepatitis B virus
Humans
Japan
Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 10403681
DOI: 10.1016/s0166-0934(99)00039-7

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