Article
HLA and schizophrenia: refutation of reported associations with A9 (A23/A24), DR4, and DQbeta1*0602.
American journal of medical genetics - 20 Aug 1999
Gibson S, Hawi Z, Straub R E, Walsh D, Kendler K S, Gill M
Abstract excerpt
The aim of this study was to test previous hypotheses of association between schizophrenia and human leukocyte antigen (HLA) specificities A9 (A23/24), DR4, and allele DQbeta1*0602. Using sequence-specific oligonucleotide probes, 256 familial schizophrenic patients and 261 unrelated controls were genotyped at polymorphisms for HLA-A, DRbeta1, and DQbeta1 loci. No significant (p < 0.05) differences in the allele...
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