Article
Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21.
American journal of medical genetics - 20 Aug 1999
Antonarakis S E, Blouin J L, Lasseter V K, Gehrig C, Radhakrishna U, Nestadt G, Housman D E, Kazazian H H, Kalman K, Gutman G, Fantino E, Chandy K G, Gargus J J, Pulver A E
Abstract excerpt
To determine the importance of a candidate gene KCNN3 (formerly named hSKCa3) in the susceptibility to schizophrenia, we have studied the genotypes of a (CAG)n polymorphism within this gene in the DNAs of the members of 54 multiplex families with this disease. Parametric and nonparametric linkage analysis did not provide evidence for linkage between KCNN3 (that we mapped to chromosome 1q21) and schizophrenia....
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