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Article

Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice.

Immunity - 1 Feb 1998

Clausen B E, Waldburger J M, Schwenk F, Barras E, Mach B, Rajewsky K, Förster I, Reith W

Abstract excerpt

Patients with major histocompatibility complex class II (MHC-II) deficiency are known to carry mutations in either the RFX complex or the trans-activator CIITA. While the pivotal role of CIITA for MHC-II gene transcription is supported by the essential absence of MHC-II molecules in CIITA-deficie...

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Source

Identifiers

PMID: 9491996
DOI: 10.1016/s1074-7613(00)80467-7

Genes

CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9491996-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice.PMID 9491996Read ↗

A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients.Semantic proximity Read ↗

The Bare Lymphocyte Syndrome and the Regulation of MHC ExpressionSemantic proximity Read ↗

[MHC class II deficiency (CIITA/RFX deficiency)].Semantic proximity Read ↗

Differential regulation of MHCII genes by PRMT6, via an AT-hook motif of RFX5.Semantic proximity Read ↗

Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class II transactivator in RFX-B-deficient cells.Semantic proximity Read ↗

Three novel mutations of the CIITA gene in MHC class II-deficient patients with a severe immunodeficiency.Semantic proximity Read ↗

Splicing defect in RFXANK results in a moderate combined immunodeficiency and long-duration clinical course.Semantic proximity Read ↗

Discoordinate expression of invariant chain and MHC class II genes in class II transactivator-transfected fibroblasts defective for RFX5.Semantic proximity Read ↗

RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.Semantic proximity Read ↗

CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation.Semantic proximity Read ↗

A patient with RFX5 variant causing an expression defect in both HLA ABC and HLA DR.Semantic proximity Read ↗

Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a multimeric phosphoprotein complexSemantic proximity Read ↗

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