Article
Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jul 1999
She J X, Ellis T M, Wilson S B, Wasserfall C H, Marron M, Reimsneider S, Kent S C, Hafler D A, Neuberg D S, Muir A, Strominger J L, Atkinson M A
Abstract excerpt
Markedly elevated levels of serum IL-4 were reported previously in 50% of a small group of type 1 diabetes nonprogessors. To determine the patterns of expression for this phenotype, a larger cohort of 58 families containing type 1 diabetic patients was examined. Analysis of the two-site ELISA assay used to measure serum IL-4 revealed evidence for heterophile antibodies, i.e., nonanalyte substances in serum...
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