Article
Chylomicron metabolism in an animal model for hyperlipoproteinemia type I.
Journal of lipid research - 1 Jul 1999
Savonen R, Nordstoga K, Christophersen B, Lindberg A, Shen Y, Hultin M, Olivecrona T, Olivecrona G
Abstract excerpt
Mink homozygous for the mutation Pro214Leu in lipoprotein lipase (LPL) had only traces of LPL activity but amounts of LPL protein in their tissues similar to those of normal mink. In normal mink, lymph chylomicrons from rats given [3H]retinol (incorporated into retinyl esters, providing a core label) and [14C]oleic acid (incorporated mainly in triglycerides (TG)) were rapidly cleared from the circulation. In the...
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