Article
Mutation testing in melanoma families: INK4A, CDK4 and INK4D.
British journal of cancer - 1 Apr 1999
Newton Bishop J A, Harland M, Bennett D C, Bataille V, Goldstein A M, Tucker M A, Ponder B A, Cuzick J, Selby P, Bishop D T
Abstract excerpt
The INK4A gene which codes for the cyclin-dependent kinase (CDK) inhibitor INK4A or p16 underlies susceptibility to melanoma in some families. Germline mutations in the gene that codes for the target protein of p16, CDK4, underlie susceptibility in very rare families. We report mutation screening of the INK4A and CDK4 genes in 42 UK families. A total of nine families were identified with INK4A mutations and none...
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