Article
Tumor DNA in plasma at diagnosis of breast cancer patients is a valuable predictor of disease-free survival.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2002
Silva Jose M, Silva Javier, Sanchez Antonio, Garcia Jose M, Dominguez Gemma, Provencio Mariano, Sanfrutos Luis, Jareño Eugenia, Colas Antonio, España Pilar, Bonilla Felix
Abstract excerpt
PURPOSE: We examine prospectively whether the presence of plasma DNA with tumor characteristics before mastectomy is a predictive factor related to recurrence and disease-free survival (DFS). EXPERIMENTAL DESIGN: A series of 147 patients with breast carcinomas, selected sequentially, was analyzed. The characterization of plasma DNA, based on similar alterations in tumor and plasma DNA, was achieved with six...
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