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Article

The A-G polymorphism in exon 1 of the CTLA-4 gene is not associated with systemic lupus erythematosus.

Annals of the rheumatic diseases - 1 Mar 1999

Heward J, Gordon C, Allahabadia A, Barnett A H, Franklyn J A, Gough S C

Abstract excerpt

OBJECTIVES: Factors contributing to the development of systemic lupus erythematosus (SLE) remain largely unknown although are likely to include both environmental and genetic components. Studies on murine lupus have indicated a role for an antibody that blocks binding of cytotoxic T lymphocyte associated-4 (CTLA-4) to B7 on antigen presenting cells in the treatment of disease, suggesting that CTLA-4 may play an...

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Identifiers

PMID: 10364920
DOI: 10.1136/ard.58.3.193
PMCID: PMC1752847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The A-G polymorphism in exon 1 of the CTLA-4 gene is not associated with systemic lupus erythematosus.PMID 10364920Read ↗

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Fc receptor gamma subunit polymorphisms and systemic lupus erythematosus.Semantic proximity Read ↗

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CTLA-4 gene exon-1 +49 A/G polymorphism: lack of association with autoimmune disease in patients with common variable immune deficiency.Semantic proximity Read ↗

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