Article
Familial relapsing haemolytic uraemic syndrome and complement factor H deficiency.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 May 1999
Warwicker P, Donne R L, Goodship J A, Goodship T H, Howie A J, Kumararatne D S, Thompson R A, Taylor C M
Abstract excerpt
BACKGROUND: In a recent study of three families we have found that inherited haemolytic uraemic syndrome (HUS) maps to a region of chromosome 1q containing the gene for complement factor H. In one of these families and also in a case of sporadic D-HUS, we have identified mutations in the factor H gene. A further family with inherited HUS has therefore been investigated. METHODS: DNA extracted from the family...
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