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Article

Characterization of human zona pellucida glycoproteins

1 Jun 1999

Abstract excerpt

The human egg may only be fertilized by one spermatozoon to prevent polyploidy. In most mammals, the primary block to polyspermy occurs at the zona pellucida (ZP). Little is known of the human ZP and the changes occurring following fertilization to prevent polyploidy. Using antibodies directed against synthetic peptides predicted from the human ZP2 and ZP3 cDNA, we identified ZP3 as a 53-60 kDa glycoprotein and...

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PMID: 10341000
DOI: 10.1093/molehr/5.6.534

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