Article
Helicobacter pylori-associated gastritis in mice is host and strain specific.
Infection and immunity - 1 Jun 1999
van Doorn N E, Namavar F, Sparrius M, Stoof J, van Rees E P, van Doorn L J, Vandenbroucke-Grauls C M
Abstract excerpt
The vacA and cagA geno- and phenotypes of two mouse-adapted strains of Helicobacter pylori, SS1 and SPM326, were determined. The SS1 strain, which had the cagA+ and vacA s2-m2 genotype, induced neither vacuole formation in HeLa cells nor interleukin-8 (IL-8) production in KATO III cells. In contrast, H. pylori SPM326, with the cagA+ and vacA s1b-m1 genotype, induced vacuoles as well as IL-8 production in vitro....
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