Article
Molecular and histological evaluation of pancreata from patients with a mitochondrial gene mutation associated with impaired insulin secretion.
Biochemical and biophysical research communications - 27 May 1999
Otabe S, Yasuda K, Mori Y, Shimokawa K, Kadowaki H, Jimi A, Nonaka K, Akanuma Y, Yazaki Y, Kadowaki T
Abstract excerpt
A mutation in mitochondrial DNA, which was originally identified in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), can be associated with a subtype of diabetes mellitus. To determine the molecular and histological basis of impaired insulin secretion in the subjects with this mutation, we studied autopsy pancreata specimens from eight subjects diagnosed as...
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