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Article

Biotin deficiency causes spontaneous cell death and activation of defense signaling.

The Plant journal : for cell and molecular biology - 1 Apr 2012

Li Jing, Brader Günter, Helenius Elina, Kariola Tarja, Palva E Tapio

Abstract excerpt

In addition to its essential metabolic functions, biotin has been suggested to play a critical role in regulating gene expression. The first committed enzyme in biotin biosynthesis in Arabidopsis, 7-keto-8-aminopelargonic acid synthase, is encoded by At5g04620 (BIO4). We isolated a T-DNA insertion mutant of BIO4 (bio4-1) with a spontaneous cell death phenotype, which was rescued both by exogenous biotin and...

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Identifiers

PMID: 22126457
DOI: 10.1111/j.1365-313X.2011.04871.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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