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Article

Suppression of a mitochondrial tRNA gene mutation phenotype associated with changes in the nuclear background.

Human molecular genetics - 1 Jun 1999

Hao H, Morrison L E, Moraes C T

Abstract excerpt

We previously have characterized a pathogenic mtDNA mutation in the tRNAAsn gene. This mutation (G5703A) was associated with a severe mitochondrial protein synthesis defect and a reduction in steady-state levels of tRNAAsn. We now show that, although transmitochondrial cybrids harboring homoplasmic levels of the mutation do not survive in galactose medium, several galactose-resistant clones could be obtained....

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Identifiers

PMID: 10332045
DOI: 10.1093/hmg/8.6.1117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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