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Article

Tumor necrosis factor-α impairs adiponectin signalling, mitochondrial biogenesis, and myogenesis in primary human myotubes cultures.

American journal of physiology. Heart and circulatory physiology - 1 May 2016

Sente Tahnee, Van Berendoncks An M, Fransen Erik, Vrints Christiaan J, Hoymans Vicky Y

Abstract excerpt

Skeletal muscle metabolic changes are common in patients with chronic heart failure (HF). Previously, we demonstrated a functional skeletal muscle adiponectin resistance in HF patients with reduced left ventricular ejection fraction (HFrEF). We aimed to examine the impact of adiponectin receptor 1 (AdipoR1) deficiency and TNF-α treatment on adiponectin signaling, proliferative capacity, myogenic differentiation,...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria, Muscle

Share to Muscle Development

Share to Muscle Fibers, Skeletal

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Share to Primary Cell Culture

Share to Receptors, Adiponectin

Source

Identifiers

PMID: 26921438
DOI: 10.1152/ajpheart.00831.2015

Genes

TNF
ACADM
APPL1
FOXO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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