Article
Genetic immunization against neu/erbB2 transgenic breast cancer.
Cancer immunology, immunotherapy : CII - 1 Dec 1998
Amici A, Venanzi F M, Concetti A
Abstract excerpt
erbB2/neu, an overexpressed oncogene product, has been proposed as a human cancer vaccine target. In the present study, transgenic (rat neuNT oncogene) FVB/neu mice, developing metastasizable mammary carcinoma, were immunized with a plasmid DNA encoding are not tolerant to the self antigen and se...
Topics
- Adenocarcinoma
- Animals
- Autoimmunity
- Breast Neoplasms
- Cancer Vaccines
- DNA, Neoplasm
- Disease Models, Animal
- Female
- Genes, erbB-2
- Humans
- Lung Neoplasms
- Mice
- Mice, Transgenic
- Mutation
- Neoplasm Transplantation
- Rats
- Receptor, ErbB-2