Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic immunization against neu/erbB2 transgenic breast cancer.

Cancer immunology, immunotherapy : CII - 1 Dec 1998

Amici A, Venanzi F M, Concetti A

Abstract excerpt

erbB2/neu, an overexpressed oncogene product, has been proposed as a human cancer vaccine target. In the present study, transgenic (rat neuNT oncogene) FVB/neu mice, developing metastasizable mammary carcinoma, were immunized with a plasmid DNA encoding are not tolerant to the self antigen and sequences. We report that transgenic tumour-bearing mice, like some breast cancer patients erbB2 + X, develop anti-neu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Disease Models, Animal
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lung Neoplasms

Share to Mice, Transgenic

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 9875670
DOI: 10.1007/s002620050519
PMCID: PMC11037311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic immunization against neu/erbB2 transgenic breast cancer.PMID 9875670Read ↗

Immunobiology of Her-2/Neu Transgenic MiceSemantic proximity Read ↗

DNA immunization using constant-current electroporation affords long-term protection from autochthonous mammary carcinomas in cancer-prone transgenic mice.Semantic proximity Read ↗

ErbB2 Transgenic Mice: A Tool for Investigation of the Immune Prevention and Treatment of Mammary CarcinomasSemantic proximity Read ↗

DNA vaccination against rat her-2/Neu p185 more effectively inhibits carcinogenesis than transplantable carcinomas in transgenic BALB/c mice.Semantic proximity Read ↗

Identification and Characterization of the Immunodominant Rat HER-2/neu MHC Class I Epitope Presented by Spontaneous Mammary Tumors from HER-2/neu-Transgenic MiceSemantic proximity Read ↗

A Better Immune Reaction to Erbb-2 Tumors Is Elicited in Mice by DNA Vaccines Encoding Rat/Human Chimeric ProteinsSemantic proximity Read ↗

HER2/neu DNA vaccination by intradermal gene delivery in a mouse tumor modelSemantic proximity Read ↗

Elimination of Progressive Mammary Cancer by Repeated Administrations of Chimeric Antigen Receptor-Modified T CellsSemantic proximity Read ↗

Combining Human and Rat Sequences in Her-2 DNA Vaccines Blunts Immune Tolerance and Drives Antitumor ImmunitySemantic proximity Read ↗

Mutational burden, MHC-I expression and immune infiltration as limiting factors for in situ vaccination by TNFα and IL-12 gene electrotransfer.Semantic proximity Read ↗

Human ErbB-2 (Her-2) Transgenic Mice: A Model System for Testing Her-2 Based VaccinesSemantic proximity Read ↗

Therapeutic HER2/Neu DNA Vaccine Inhibits Mouse Tumor Naturally Overexpressing Endogenous NeuSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.