Article
A new contributing factor to polycystic ovary syndrome: the genetic variant of luteinizing hormone.
The Journal of clinical endocrinology and metabolism - 1 May 1999
Tapanainen J S, Koivunen R, Fauser B C, Taylor A E, Clayton R N, Rajkowa M, White D, Franks S, Anttila L, Pettersson K S, Huhtaniemi I T
Abstract excerpt
Although the etiology of polycystic ovary syndrome (PCOS) is still unclear, LH is considered to play a central role in its pathogenesis. An immunologically anomalous form of LH, with two point mutations in the LHbeta gene, has been recently described. This genetic variant of LH (v-LH), of wide geographic distribution, is functionally different from wild-type (wt) LH. To assess the role of the v-LH in PCOS, we...
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