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Article

Nitric oxide signaling is disrupted in the yeast model for Batten disease.

Molecular biology of the cell - 1 Jul 2007

Osório Nuno S, Carvalho Agostinho, Almeida Agostinho J, Padilla-Lopez Sérgio, Leão Cecília, Laranjinha João, Ludovico Paula, Pearce David A, Rodrigues Fernando

Abstract excerpt

The juvenile form of neuronal ceroid lipofuscinoses (JNCLs), or Batten disease, results from mutations in the CLN3 gene, and it is characterized by the accumulation of lipopigments in the lysosomes of several cell types and by extensive neuronal death. We report that the yeast model for JNCL (btn...

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Source

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Identifiers

PMID: 17475770
DOI: 10.1091/mbc.e06-11-1053
PMCID: PMC1924819

Genes

CLN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17475770-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Nitric oxide signaling is disrupted in the yeast model for Batten disease.PMID 17475770Read ↗

Absence of Btn1p in the yeast model for juvenile Batten disease may cause arginine to become toxic to yeast cells.Semantic proximity Read ↗

Current Insights in Elucidation of Possible Molecular Mechanisms of the Juvenile Form of Batten Disease.Semantic proximity Read ↗

The Batten disease gene CLN3 is required for the response to oxidative stress.Semantic proximity Read ↗

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Action of BTN1, the yeast orthologue of the gene mutated in Batten disease.Semantic proximity Read ↗

Defective lysosomal arginine transport in juvenile Batten disease.Semantic proximity Read ↗

Biosynthesis and Intracellular Targeting of the CLN3 Protein Defective in Batten DiseaseSemantic proximity Read ↗

Batten disease: evaluation of CLN3 mutations on protein localization and functionSemantic proximity Read ↗

A mouse gene knockout model for juvenile ceroid-lipofuscinosis (Batten disease).Semantic proximity Read ↗

Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected].Semantic proximity Read ↗

Defective intracellular transport of CLN3 is the molecular basis of Batten disease (JNCL)Semantic proximity Read ↗

Deletion of the Caenorhabditis elegans homologues of the CLN3 gene, involved in human juvenile neuronal ceroid lipofuscinosis, causes a mild progeric phenotype.Semantic proximity Read ↗

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