Article
Differential binding of viral peptides to HLA-A2 alleles. Implications for human papillomavirus type 16 E7 peptide-based vaccination against cervical carcinoma.
European journal of immunology - 1 Apr 1999
Ressing M E, de Jong J H, Brandt R M, Drijfhout J W, Benckhuijsen W E, Schreuder G M, Offringa R, Kast W M, Melief C J
Abstract excerpt
Several cancer immune intervention protocols aim at inducing T cell immunity against antigens presented by HLA-A2, the most common human MHC class I molecule. In the context of HLA-A*0201, we previously identified two cytotoxic T lymphocyte epitopes (E7(11-20) and E7(86-93)) encoded by the human papillomavirus type 16 E7 (HPV16 E7) oncoprotein, which is a tumor-specific antigen for cervical carcinoma. This study...
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