Article
Joint action of two RNA degradation pathways controls the timing of maternal transcript elimination at the midblastula transition in Drosophila melanogaster.
The EMBO journal - 4 May 1999
Bashirullah A, Halsell S R, Cooperstock R L, Kloc M, Karaiskakis A, Fisher W W, Fu W, Hamilton J K, Etkin L D, Lipshitz H D
Abstract excerpt
Maternally synthesized RNAs program early embryonic development in many animals. These RNAs are degraded rapidly by the midblastula transition (MBT), allowing genetic control of development to pass to zygotically synthesized transcripts. Here we show that in the early embryo of Drosophila melanogaster, there are two independent RNA degradation pathways, either of which is sufficient for transcript elimination....
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