Article
Peutz-Jeghers syndrome: 78-year follow-up of the original family.
Lancet (London, England) - 10 Apr 1999
Westerman A M, Entius M M, de Baar E, Boor P P, Koole R, van Velthuysen M L, Offerhaus G J, Lindhout D, de Rooij F W, Wilson J H
Abstract excerpt
BACKGROUND: The association between heredity, gastrointestinal polyposis, and mucocutaneous pigmentation in Peutz-Jeghers syndrome (PJS) was first recognised in 1921 by Peutz in a Dutch family. This original family has now been followed-up for more than 78 years. We did mutation analysis in this family to test whether the recently identified LKB1 gene is indeed the PJS gene in this family. METHODS: The original...
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