Article
Development and characterization of new flavivirus-resistant mouse strains bearing Flv(r)-like and Flv(mr) alleles from wild or wild-derived mice.
The Journal of general virology - 1 Apr 1999
Urosevic N, Silvia O J, Sangster M Y, Mansfield J P, Hodgetts S I, Shellam G R
Abstract excerpt
A single genetic locus, flavivirus resistance (Flv), controls virus titres and severity of flavivirus infection in mouse brain. It has been mapped to mouse chromosome 5 and shown to include different allelic forms. While the majority of laboratory mouse strains are susceptible to flaviviruses and carry the Flv(s) allele, wild mice and laboratory mouse strains recently derived from them are resistant and carry...
Topics
- Alleles
- Animals
- Chromosome Mapping
- Flavivirus Infections
- Genetic Predisposition to Disease
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Polymorphism, Genetic
- Species Specificity
- Virus Replication