Correction of neutropenia and hypogammaglobulinemia in X-linked hyper-IgM syndrome by allogeneic bone marrow transplantation.

doi:10.1038/sj.bmt.1701512

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Article

Correction of neutropenia and hypogammaglobulinemia in X-linked hyper-IgM syndrome by allogeneic bone marrow transplantation.

Bone marrow transplantation - 1 Dec 1998

Scholl P R, O'Gorman M R, Pachman L M, Haut P, Kletzel M

Abstract excerpt

X-linked hyper-IgM (X-HIM) syndrome is a primary immunodeficiency disease characterized by defects in both cellular and humoral immunity. X-HIM is caused by mutations in the gene for CD40 ligand (CD40L), a T cell membrane protein that mediates T cell-dependent immune functions. We report the case...

Topics

Agammaglobulinemia
Bone Marrow Transplantation
CD40 Ligand
Child
Humans
Immunoglobulin M
Male
Membrane Glycoproteins
Mutation
Neutropenia
Transplantation, Homologous
X Chromosome

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