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Article

Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.

Nature neuroscience - 1 Sept 1998

Hardy J, Duff K, Hardy K G, Perez-Tur J, Hutton M

Abstract excerpt

Molecular genetic analysis is revealing the etiologies of Alzheimer's disease (AD) and related dementias. Here we review genetic and molecular biological evidence suggesting that the peptide A beta 42 is central to the etiology of AD. Recent data also suggests that dysfunction in the cytoskeletal protein tau is on the pathway that leads to neurodegeneration and dementia. Tau is produced either indirectly, by A...

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Source

Identifiers

PMID: 10196523
DOI: 10.1038/1565

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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