Article
DEAD-box protein HEL64 from Trypanosoma brucei: subcellular localization and gene knockout analysis.
Parasitology research - 1 Apr 1999
Missel A, Lambert L, Nörskau G, Göringer H U
Abstract excerpt
RNA helicases are molecules that play a central role in the control of ribonucleic acid metabolism. Only two putative RNA helicase genes of the DEAD-box family have been identified in the protozoan parasite Trypanosoma brucei brucei. One of these genes is HEL64, a single-copy gene of unknown function. In this study we conducted targeted gene-disruption experiments of the HEL64 locus with the aim of identifying a...
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