Article
Loss of transformed phenotype in cancer cells by overexpression of the uteroglobin gene.
Proceedings of the National Academy of Sciences of the United States of America - 30 Mar 1999
Zhang Z, Kundu G C, Panda D, Mandal A K, Mantile-Selvaggi G, Peri A, Yuan C J, Mukherjee A B
Abstract excerpt
Uteroglobin (UG) is a multifunctional, secreted protein that has receptor-mediated functions. The human UG (hUG) gene is mapped to chromosome 11q12.2-13.1, a region frequently rearranged or deleted in many cancers. Although high levels of hUG expression are characteristic of the mucosal epithelia of many organs, hUG expression is either drastically reduced or totally absent in adenocarcinomas and in...
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