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Article

Insight into the physiological function(s) of uteroglobin by gene-knockout and antisense-transgenic approaches.

Annals of the New York Academy of Sciences - 1 Jan 2000

Zhang Z, Kundu G C, Zheng F, Yuan C J, Lee E, Westphal H, Ward J, DeMayo F, Mukherjee A B

Abstract excerpt

To determine the physiological function(s) of uteroglobin (UG), a steroid-inducible, homodimeric, secreted protein, we have generated transgenic mice that either are completely UG-deficient due to UG gene-knockout (UG-KO) or are partially UG-deficient due to the expression of UG antisense RNA (UG-AS). Both the UG-KO and UG-AS mice develop immunoglobulin A (IgA) nephropathy (IgAN), characterized by microhematuria,...

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Identifiers

PMID: 11193759
DOI: 10.1111/j.1749-6632.2000.tb05532.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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