Article
Modulation of endocytosis in nuclear factor IL-6(-/-) macrophages is responsible for a high susceptibility to intracellular bacterial infection.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1999
Pizarro-Cerdá J, Desjardins M, Moreno E, Akira S, Gorvel J P
Abstract excerpt
Activated macrophages kill bacteria, a function known to depend on the expression of NF-IL-6. Here, it is demonstrated that the attenuated Brucella abortus vaccine strain 19 replicates much better in NF-IL-6-/- than in NF-IL-6(+/+) and NF-IL-6(+/+)-activated murine macrophages and at levels comparable to those observed in normal macrophages infected with the pathogenic strain 2308. The role of NF-IL-6 in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.