Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of a polymorphism of the 5HT2A receptor gene promoter region with alcohol dependence.

Molecular psychiatry - 1 Jan 1999

Nakamura T, Matsushita S, Nishiguchi N, Kimura M, Yoshino A, Higuchi S

Abstract excerpt

Approximately 10% of Japanese alcoholics develop their disease despite having an inactive form of aldehyde dehydrogenase-2 (ALDH2), known as a genetic deterrent of heavy drinking due to adverse reactions after drinking. Such alcoholics are considered to be advantageous in genetic research because they should show reduced heterogeneity and possess genetic factors conferring susceptibility to alcohol dependence....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism
Share to Aldehyde Dehydrogenase
Share to Aldehyde Dehydrogenase, Mitochondrial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Receptor, Serotonin, 5-HT2A

Share to Receptors, Serotonin

Share to Reference Values

Source

Identifiers

PMID: 10089015
DOI: 10.1038/sj.mp.4000474

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of a polymorphism of the 5HT2A receptor gene promoter region with alcohol dependence.PMID 10089015Read ↗

Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2.Semantic proximity Read ↗

Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism.Semantic proximity Read ↗

Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disorders.Semantic proximity Read ↗

Alcoholism, ALDH2*2 allele and the A1 allele of the dopamine D2 receptor gene: an association study.Semantic proximity Read ↗

Review: Use of Asian samples in genetic research of alcohol use disorders: Genetic variation of alcohol metabolizing enzymes and the effects of acetaldehyde.Semantic proximity Read ↗

Influence of Comorbid Psychiatric Disorders on the Risk of Development of Alcohol Dependence by Genetic Variations of ALDH2 and ADH1B.Semantic proximity Read ↗

A Novel Polymorphism (‐357 G/A) of the ALDH2 Gene: Linkage Disequilibrium and an Association With AlcoholismSemantic proximity Read ↗

Association of an aldehyde dehydrogenase 2 (ALDH2) gene polymorphism with hyper-low-density lipoprotein cholesterolemia in a Japanese population.Semantic proximity Read ↗

Effects of functional polymorphisms related to catecholaminergic systems on changes in blood catecholamine and cardiovascular measures after alcohol ingestion in the Japanese population.Semantic proximity Read ↗

Dopamine transporter gene polymorphism and alcoholism.Semantic proximity Read ↗

An investigation of associations between alcohol use disorder and polymorphisms on ALDH2, BDNF, 5-HTTLPR, and MTHFR genes in older Korean men.Semantic proximity Read ↗

Impaired Regulation of ALDH2 Protein Expression Revealing a Yet Unknown Epigenetic Impact of rs886205 on Specific Methylation of a Negative Regulatory Promoter Region in Alcohol-Dependent Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.