Article
Optimisation of HLA-B27 testing by association of flow cytometry and DNA typing.
Clinical rheumatology - 1 Jan 1999
Bonnaud G, Aupetit C, Preux P M, Cogné M, Drouet M
Abstract excerpt
HLA-B27 typing contributes to the diagnosis of ankylosing spondylitis. The classical technique of microlymphocytotoxicity is costly and can give false-negative results. We have compared 304 samples using two relatively new methods - flow cytometry and PCR-SSP - and evaluated their respective uses in routine analysis. Flow cytometric HLA-B27 testing was performed using three monoclonal anti-B27 antibodies...
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