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Article

Proliferative fraction, bcl-1 gene translocation, and p53 mutation status as markers in mantle cell lymphoma.

International journal of molecular medicine - 1 Apr 1999

Fiel-Gan M D, Almeida L M, Rose D C, Takano A, Rezuke W N, Coleman W B, Garcia N F, Tsongalis G J

Abstract excerpt

The molecular genetic hallmark of mantle cell lymphomas (MCL) is the reciprocal translocation t(11;14)(q13;q32) which juxtaposes the bcl-1 proto-oncogene to one of the joining segments of the immunoglobulin heavy chain gene. This translocation is very common in MCL and occurs in up to 70% of these malignancies. Due to the aggressive nature of MCL, markers identifying tumor progression and clinical outcomes are...

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Identifiers

PMID: 10085408
DOI: 10.3892/ijmm.3.4.373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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