Article
Endothelial cells do not express GSTA1: potential relevance to busulfan-mediated endothelial damage during haematopoietic stem cell transplantation.
European journal of haematology - 1 Apr 2008
Vassord Camille, Lapouméroulie Claudine, Koumaravelou Kailasam, Srivastava Alok, Krishnamoorthy Rajagopal
Abstract excerpt
Busulfan-mediated endothelial damage is believed to be a common mechanism in a variety of vascular disorders that occur during haematopoietic stem cell transplantation. The alkylating capacity of busulfan is compromised in vivo by enzymatic conjugation with glutathione, principally catalysed by glutathione S-transferase alpha (GST alpha). We investigated whether the susceptibility of endothelial cells to...
Topics
- Busulfan
- Cells, Cultured
- Endothelial Cells
- Genotype
- Glutathione Transferase
- Hematopoietic Stem Cell Transplantation
- Humans
- Promoter Regions, Genetic