Article
The HIV type 1 protease inhibitor saquinavir can select for multiple mutations that confer increasing resistance.
AIDS research and human retroviruses - 1 Mar 1999
Vaillancourt M, Irlbeck D, Smith T, Coombs R W, Swanstrom R
Abstract excerpt
Previous use of the HIV-1 protease inhibitor saquinavir resulted in the infrequent appearance of mutations in the HIV-1 protease gene associated with resistance. We have examined the ability of saquinavir to select for resistance mutations. In multiple selections of HIV-1 in cell culture with saquinavir, similar patterns of mutations were reproducibly observed and the number of mutations increased with increasing...
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