Article
The role of apoptosis in neuromuscular diseases and prospects for anti-apoptosis therapy.
Trends in molecular medicine - 1 Jun 2006
Miller Jeffrey B, Girgenrath Mahasweta
Abstract excerpt
Although genetic mutations that are responsible for most of the inherited neuromuscular diseases have been identified, the molecular and cellular mechanisms that cause muscle and nerve depletion are not well understood and therapies are lacking. Histological studies of many neuromuscular diseases indicated that loss of motor-nerve and/or skeletal-muscle function might be due to excessive cell death by apoptosis....
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